We provide support for large-scale functional annotations of proteins. These annotations are performed by integrating results from state-of-the-art methods and web-resources developed worldwide. The methods and resources we exploit range from classical sequence-based comparative genomics methods (reciprocal Blasts & profile-based methods) to those exploiting information on known protein 3D structures (threading & homology modeling). We also integrate information on protein interactions and genetic interactions.
Organization of functional modules involved in chromosome biology. Depicted is the network of functional modules identified by the Local Coherence Detection algorithm (developed by Wodak Lab) from the E-MAP data of Collins et al. (Collins, 2007). Nodes represent complexes or known epistasis groups identified here as genetic modules. The node size is proportional to the number of genes and edge thickness is proportional to the number of modules that contain the linked nodes.
