The CCB offers expertise in interpreting data on groups of genes (identified by differential transcriptomics) or groups of differentially expressed proteins, in terms of the network of functional and physical interactions in which these genes or proteins engage. We offer access to integrated datasets of interactions and cellular pathways of model organisms (including human) obtained from public sources. We also build customized high quality integrated datasets focusing on specific diseases and processes using a variety of public databases. Access to and usage of versatile and interactive networks visualization software is also available.
All work related to Network and Pathyways anaylsis is carried out in close collaborition with the Wodak Lab Research Group.
The networks titled "human PROTEIN VIEW" and "yeast PROTEIN VIEW" represent protein-protein interactions between proteins in the neighbourhood of TAF12.
On the left are domain-domain interactions that correspond to the protein networks. On the right are gene-gene interactions that correspond to the protein networks.
Upon highlighting TAF12 in human (giving a yellow colour), all domains that belong to TAF12 are lit up, and all genes that code for TAF12 are also lit up. Furthermore, orthologous proteins in the yeast network and its corresponding domains and genes are also lit up.
Light blue nodes represent proteins and pink nodes represent domains and genes. Nodes of other colours other than yellow represent orthology. For example TBP which is coloured magenta is orthologous to SPT15 which is also coloured magenta.
Finally, shapes represent diseases. In this particular case:
Triangle = Chondrosarcoma, extraskeletal myxoid, 612237 (1).
Square = Huntington disease-like-4, 607136 (3).
Hexagon = Dystonia-Parkinsonism, X-linked, 314250 (3).
An ellipse shape means that node is not associated with particular diseases the user has selected.
